Cassopolis is located in central Cass County in the southwestern corner of Michigan’s Lower Peninsula.  Specifically, Cassopolis is located in the southeastern corner of LaGrange Township, although a portion of the east side of the Village extends into Penn Township as well. Jefferson Township borders the Village to the south.

The Village is a traditional Midwestern small town.  It has an older, urban core surrounded by traditional residential neighborhoods.  The Village serves as the County Seat for Cass County and is home to the majority of the County offices, the County Courthouse, and the County Fairgrounds.

Two state highways intersect in Cassopolis: M-60 and M-62.  M-60 travels to Jackson and Three-Rivers to the east and Niles to the southwest.  It provides access to US-31, US-131, and I-69.  M-62 connects residents to South Bend and Granger, Indiana to the south as well as Dowagiac to the north.  It also provides access to US-12.  The Village is situated about 35 miles northeast of South Bend and is a part of the South Bend Metropolitan Statistical Area for census purposes.